I’m going to go out on a limb and assume that a comparison between the Trump and Biden administrations in efforts to police the telecom industry would show a marked difference in both effort and effectiveness.
The regulatory difference between the Trump and Biden administrations is largely reflected in their FCC chairs, and so you'd look at policy interventions and enforcement under these two:
For Rosenworcel, her primary focus seems to be a focus on restoring Net Neutrality. For Pai, his primary focus was on its repeal. The two both share a focus on broadband access and marketing radio spectrum. In terms of banter, Pai is certainly more of a "the free market" personality, and Rosenworcel is more of a "top-down regulation" personality.
Regarding impact, I would characterize their offices as substantially unique only in the context of Net Neutrality.
