I especially like your last paragraph. Even if our fundamental assumptions are wrong, current theories still work very well within appropriate bounds. And those bounds basically contain all practical scenarios here on earth. That's a big reason why it's hard to make progress on string theory, because we can't create scenarios extreme enough here on earth to test it.

So even if our fundamental assumptions are wrong and some new theory is able to explain a bunch of new stuff, chances are it won't impact the stuff we can practically do here on earth, because scientists have already been doing the most extreme experiments they can, and so far progress is still stalled on fundamental physics.